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. 2008 Sep 5;118(10):3378–3389. doi: 10.1172/JCI34587

Figure 5. Chop-null mutation in Leprdb/db mice increases expression of UPR and antioxidative stress response genes and decreases expression of proapoptotic genes.

Figure 5

Real-time RT-PCR analysis of islet mRNA expression. Expression values were normalized to 18S rRNA and are presented as fold-induction compared with wild-type (Leprdb/+Chop+/+) islets. (A) UPR genes and ER-associated protein degradation genes. (B) Control genes. (C) CHOP-regulated genes and other death signaling genes. (D) Antioxidative stress genes. Chop mRNA was not detectable in Leprdb/+Chop–/– or Leprdb/dbChop–/– islets; n = 4–6 mice per condition. *P < 0.05, **P < 0.01, ***P < 0.001 for Leprdb/dbChop+/+ compared with Leprdb/dbChop–/–.