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. 2008 Sep 16;3(9):e3218. doi: 10.1371/journal.pone.0003218

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Berg et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(Aa) SFA in intracellular recording from motoneuron in slice during NMDA induced bursting. (Ab) Single burst highlighted in (Aa) show gradual increase in ISI. (Ac) Histogram of ISI. The mean ISI is 55 ms (arrow). (Ad) Plot of ISI_N against ISI_N+1 shows significantly greater proportion of points above than below the ISI_N = ISI_N+1 line (83.2% above, total N = 239), which is evidence of spike frequency adaptation. In addition, ISIs are correlated with their neighbors (correlation coefficient = 0.41), as expected when ISI are influenced by AHP conductance and the burst pattern is reproduced after 10 spikes (Ae). Gray area represents the 5% confidence limit (Ba) Recording from a MN in a functional spinal network during rhythmic motor activity. (Bb) A hightligted cycle from (Ba) shows irregular spike times and no SFA. (Bc) Histogram of ISI. The mean ISI is 34 ms (arrow) (Bd) A plot of ISI_N against ISI_N+1 illustrates no discrepancy of points above and below the ISI_N = ISI_N+1 line (51.3% above, total N = 362), which demonstrates absence of SFA. Furthermore, there is only a marginal correlation of ISI with neighbors (correlation coefficient = 0.18), as expected with negligible AHP conductance (Be). Gray area represents the 5% confidence limit . Tick marks to the left represent −80 mV (A) and −60 mV (B). Inter-burst-intervals are omitted in analysis.

Inline graphic — (Aa) SFA in intracellular recording from motoneuron in slice during NMDA induced bursting. (Ab) Single burst highlighted in (Aa) show gradual increase in ISI. (Ac) Histogram of ISI. The mean ISI is 55 ms (arrow). (Ad) Plot of ISI_N against ISI_N+1 shows significantly greater proportion of points above than below the ISI_N = ISI_N+1 line (83.2% above, total N = 239), which is evidence of spike frequency adaptation. In addition, ISIs are correlated with their neighbors (correlation coefficient = 0.41), as expected when ISI are influenced by AHP conductance and the burst pattern is reproduced after 10 spikes (Ae). Gray area represents the 5% confidence limit (Ba) Recording from a MN in a functional spinal network during rhythmic motor activity. (Bb) A hightligted cycle from (Ba) shows irregular spike times and no SFA. (Bc) Histogram of ISI. The mean ISI is 34 ms (arrow) (Bd) A plot of ISI_N against ISI_N+1 illustrates no discrepancy of points above and below the ISI_N = ISI_N+1 line (51.3% above, total N = 362), which demonstrates absence of SFA. Furthermore, there is only a marginal correlation of ISI with neighbors (correlation coefficient = 0.18), as expected with negligible AHP conductance (Be). Gray area represents the 5% confidence limit . Tick marks to the left represent −80 mV (A) and −60 mV (B). Inter-burst-intervals are omitted in analysis.