Table 1.

Two-locus haplotype transmissions of HLA-DRB1*15−HLA-A and HLA-DRB1*X−HLA-A from HLA-DRB1*15 positive (n = 536) and negative parents (n = 452)

HLA-DRB1*15 Positive Parents (n = 536)						HLA-DRB1*15 Negative Parents (n = 452)						Comparison
Haplotypes	TR	NT	OR	χ2	P	Haplotypes	TR	NT	OR	χ2	P	χ2	P
15-1	51	26	1.96	8.27	0.0040	X-1	119	113	1.05	0.16	0.69	5.21	0.022
15-2	136	55	2.47	34.81	3.64 × 10−9	X-2	145	157	0.92	0.48	0.49	25.67	1.051 × 10−7
15-3	140	59	2.37	33.95	5.67 × 10−9	X-3	93	73	1.27	2.41	0.12	8.048	0.0046
15-11	41	24	1.71	4.50	0.034	X-11	50	42	1.19	0.70	0.40	1.19	0.28
15-23	4	1	4.00	1.93	0.17	X-23	13	12	1.08	0.04	0.84	—†	0.22
15-24	92	22	4.18	46.20	1.07 × 10−11	X-24	51	63	0.81	1.26	0.26	31.53	1.96 × 10−8
15-25	20	5	4.00	9.64	0.0019	X-25	13	7	1.86	1.80	0.18	—†	0.14
15-26	11	9	1.22	0.20	0.65	X-26	12	27	0.44	5.77	0.016	—†	0.046
15-29	4	16	0.25	7.71	0.0055	X-29	14	12	1.17	0.15	0.69	5.44	0.020
15-30	6	20	0.30	7.95	0.0048	X-30	9	15	0.60	1.50	0.22	1.24	0.27
15-31	2	4	0.50	0.68	0.41	X-31	17	12	1.42	0.86	0.35	—†	0.19
15-32	10	4	2.50	2.66	0.10	X-32	12	15	0.80	0.33	0.56	—†	0.071
15-33	2	10	0.20	5.82	0.016	X-33	5	11	0.45	2.25	0.13	0.78	0.38
15-68	10	5	2.00	1.70	0.19	X-68	24	37	0.65	2.77	0.10	—†	0.039
TOTAL	529	260	2.035	91.71	1.00 × 10−21	TOTAL	577	596	0.97	0.31	0.58	61.16	5.26 × 10−15

HLA-DRB1*X refers to any allele other than HLA-DRB1*15.

^†Fisher's exact test was used when the expected transmissions in any of the cells of the table were below 10. Uninformative MS families were excluded in this analysis, which may contain parents homozygous for both class I/II, and/or HLA identical parents for both class I/II, and/or with missing class I/II typing.