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. 2008 Aug 27;105(35):12820–12824. doi: 10.1073/pnas.0806121105

Table 2.

Potencies of FAAH inhibitors for hFAAH, rFAAH, and h/rFAAH: kinact/KI values

Compound Structures kinact/KI, M−1s−1
 Potency ratio
hFAAH rFAAH h/rFAAH hFAAH/rFAAH
1(PF-750) graphic file with name zpq999084470g001.jpg 791 ± 34 104 ± 14 528 ± 53 7.6
2(PF-622) graphic file with name zpq999084470g002.jpg 621 ± 130 154 ± 67 623 ± 250 4.0
3 graphic file with name zpq999084470g003.jpg 2,110 ± 230 322 ± 120 1,960 ± 1,100 6.6
4 graphic file with name zpq999084470g004.jpg 468 ± 53 18.2 ± 8.2 415 ± 65 26
5 graphic file with name zpq999084470g005.jpg 1,520 ± 340 362 ± 32 1,300 ± 590 4.2

kinact/KI values were determined as described in Methods and by using Km values shown in Table 1. The concentrations of inhibitors varied from 0.012 to 25 μM. Values are averages ± SD of two independent experiments.