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. 2008 Aug 26;105(35):12961–12966. doi: 10.1073/pnas.0806180105

Fig. 3.

Fig. 3.

Electrophysiological characterizations of striatum properties in knockout and control mice. (A) Measurements of NMDA and AMPA currents in striatal slices from control (Left) and mutant mice (Right). NR1 mutants lack functional synaptic NMDA receptors in striatal neurons. Examples of EPSCs from neurons in control and NR1 mutant mice. (Scale bars, 100 ms and 20 pA.) (B) Mean NMDA receptor/AMPA receptor ratios from control and NR1 mutant groups (n = 6 from three animals in each group). Error bars represent SEM (**, P < 0.0001, Student's t test). (C) Current–voltage (I–V) relationships of AMPA receptor-mediated EPSCs in control mice and mutant mice. (Inset) Examples of evoked AMPA receptor EPSCs at membrane potentials from −80 to +40 mV. (Scale bar, 50 pA and 20 ms; n = 6 from three animals per group; r = 0.99 for each group.) (D) Local field potentials measured in P16 pups. Data from two representative mice of the control and mutant groups are shown. The population oscillatory frequencies at the gamma range (30–80 Hz) are greatly diminished in conditional knockout mice (n = 6; n = 4 in control mice).