Fig. 5.

Hyperactivity of P16 mutants in novelty-induced locomotor activity test. (A) Indistinguishable locomotor actvitity in P9 mutants compared with that of control mice in the novelty-induced locomotion test (mean +/− SEM, n = 11, 15, 13, 14, 15, and 14, in the same order of genotype shown in the graph). (B) Hyperactivity of P16 mutant (mean +/− SEM, n = 13 11, 15, 16, 19, and 13, in the order shown in the graph). Mutant pups were significantly hyperactive in both ambulatory activity and fine movements compared with all other genotypes (post hoc test, **, P < 0.01).