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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Biol Psychiatry. 2008 Apr 18;64(3):175–183. doi: 10.1016/j.biopsych.2008.03.006

Figure 1.

Figure 1

Naloxone precipitated morphine withdrawal in animals chronically treated with morphine is attenuated following pretreatment with an Ox1r antagonist. Animals pretreated with SB-334867 prior to naloxone (black bar, n=9) are compared with those pretreated with saline prior to naloxone (white bar, n=9) and with animals pretreated with SB-334867 (gray bar, n=9) or saline (white striped bar, n=9) prior to a saline control injection for the noted signs or the global withdrawal score. Vertical lines represent the standard error of the mean (SEM). * represents a significant naloxone effect (P<0.05). ** represents a significant naloxone interaction with SB-334867 (P<0.05).