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. 2008 Jul 25;8:219. doi: 10.1186/1471-2148-8-219

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Copyright ©2008 Paris et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The amphioxus ER acts as a dominant negative estrogen receptor. A pSG5 construct containing human ERα (A) or human ERβ (B) was tested in transfected HeLa cells for its ability to activate the co-transfected cognate ERE-luc reporter plasmid after E₂stimulation (10^-6M) in presence of increasing doses of the amphiER construct. (C) A pSG5 construct containing human ERβ was tested in transfected HeLa cells for its ability to activate the co-transfected ps2 promoter after E₂stimulation (10^-6M) in the presence of increasing doses of the amphiER construct.