Table 2.

24 loci identified by MLDA, PAM and SAM as differentially methylated candidates in the comparison between A2780 cisplatin sensitive and cisplatin multiple-selected resistant cell lines.

microarray ID	status	validation	MLDA rank*	PAM rank	SAM rank	CGI***	gene symbol**	GenBank Accession	Chromosome
66_G_6	hypermethylated	Yes	1	1	1	Yes
121_D_9	hypermethylated	Yes	2	5	6	Yes	CRABP1	NM_004378	15
39_E_1	hypermethylated	ND	3	2	2	No
122_D_9	hypermethylated	No	4	11	11	Yes	SOX12	NM_006943	20
123_D_9	hypermethylated	No	5	10	10	Yes	SOX12	NM_006943	20
51_H_8	hypermethylated	Yes	6	18	19	No	FEZF2	NM_018008	3
58_A_1	hypermethylated	ND	7	22	22	Yes
80_H_5	hypermethylated	ND	8	14	16	No
21_A_11	hypermethylated	Yes	9	17	18	Yes	NTN4	NM_021229	12
38_D_7	hypermethylated	Yes	11	23	24	Yes	AGBL2	NM_024783	11
40_E_1	hypermethylated	ND	12	19	17	No
18_A_7	hypermethylated	ND	13	20	20	No	EDIL3	NM_005711	5
55_F_8	hypermethylated	Yes	14	9	9	Yes	BC127881	BC127881	7
122_B_1	hypermethylated	ND	15	16	14	No
109_A_6	hypermethylated	No	18	12	13	Yes
41_D_9	hypermethylated	Yes	22	8	8	Yes	WNT1	NM_005430	12
42_D_9	hypermethylated	ND	23	4	4	No
119_A_6	hypermethylated	Yes	24	6	5	Yes	NR2E1	NM_003269	6
63_A_8	hypermethylated	ND	26	15	15	No
6_D_4	hypermethylated	Yes	31	3	3	Yes	LMX1A	NM_177398	1
17_H_9	hypermethylated	Yes	34	13	12	Yes	HRASLS3	NM_006290	6
5_D_4	hypermethylated	Yes	35	7	7	Yes	LMX1A	NM_177398	1
24_D_3	hypermethylated	Yes	75	24	23	Yes	SP5	NM_001003845	2
122_G_1	hypermethylated	ND	101	21	21	Yes

ND: not done. Yes: validated. No: not validated

MLDA rank*: the rank of standardised residuals to the robust regression line constructed by the averaged sensitive scores against averaged resistant scores

Gene symbol**: only the gene of which transcription start site (TSS) is within 5 kb span of the loci

CGI***: CpG island defined by Gardiner-Garden and Frommer [31].