Table 2.

Summary of efficacy in antidepressant meta-analysis

		Number of		Percent with
Antidepressant	Outcome	Trials	Patients	Placebo	Active	Relative benefit (95% CI)	NNT (95% CI)
Duloxetine 60/120 mg	at least 50% pain relief	3	1,024	27	47	1.7 (1.4 to 2.1)	5.1 (3.9 to 7.3)
Amitriptyline all doses	global improvement	10	588	32	64	2.0 (1.6 to 2.4)	3.2 (2.6 to 4.2)
Other antidepressants	global improvement	3	216	12	50	4.2 (2.5 to 7.0)	2.6 (2.0 to 3.7)
Venlafaxine all doses	global improvement	3	200	25	57	2.3 (1.6 to 3.4)	3.1 (2.2 to 5.1)
Desipramine all doses	global improvement	2	78	10	59	5.8 (2.2 to 15)	2.1 (1.5 to 3.3)
Imipramine all doses	global improvement	2	58	5	97	19 (3.9 to 89)	1.1 (1.0 to 1.2)

NNT – Number need to treat