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. 2008 Sep 16;3(9):e3224. doi: 10.1371/journal.pone.0003224

Table 1. Characterization of proteins significantly over-represented in diabetic serum compared to non-diabetic serum based on LSPAD method. (P<0.01).

IPI ID Protein name Diabetic peptide spectral count Non-diabetic peptide spectral count P value
IPI00022434 ALB protein 61457 47082 4.09E-91
IPI00514824 Complement component C4B 875 183 1.44E-80
IPI00555805 Complement component 4A 3896 2109 1.63E-69
IPI00032258 Complement C4 precursor 3846 2077 3.06E-69
IPI00453459 Complement Component 4B preproprotein 3933 2141 9.77E-69
IPI00418163 C4B1 3811 2077 2.48E-66
IPI00384697 ALB protein 47105 37323 6.64E-37
IPI00556148 Complement factor H 2732 1691 1.30E-30
IPI00465313 Alpha 2 macroglobulin variant 17016 13013 7.50E-26
IPI00478003 Alpha-2-macroglobulin precursor 17344 13335 3.06E-24
IPI00385264 Ig mu heavy chain disease protein 1614 880 4.42E-23
IPI00164623 Complement C3 precursor 9754 7267 8.64E-22
IPI00479708 Immunoglobulin heavy constant mu (IGHM) 2007 1204 1.02E-21
IPI00549273 Immunoglobulin heavy constant mu (IGHM) 1995 1190 3.09E-21
IPI00019943 Afamin precursor 553 221 1.57E-20
IPI00479169 65 kDa protein 1932 1181 2.35E-18
IPI00022488 Hemopexin precursor 1952 1268 2.99E-14
IPI00426051 Hypothetical protein DKFZp686C15213 5203 3835 6.18E-14
IPI00021727 C4b-binding protein alpha chain precursor 638 321 1.01E-13
IPI00478493 Haptoglobin precursor 4214 3100 7.28E-12
IPI00550991 Alpha-1-antichymotrypsin precursor 1088 628 2.99E-11
IPI00019591 Splice Isoform 1 of Complement factor B precursor 1183 696 4.42E-11
IPI00021842 Apolipoprotein E precursor 394 181 3.28E-10
IPI00019399 Serum amyloid A-4 protein precursor 143 43 9.21E-10
IPI00021857 Apolipoprotein C-III precursor 144 49 3.87E-08
IPI00022392 Complement C1q subcomponent, A chain precursor 103 30 1.25E-07
IPI00021841 Apolipoprotein A-I precursor 4069 3112 2.14E-07
IPI00010865 Casein kinase II beta subunit 23 0 2.70E-07
IPI00396929 PREDICTED: similar to immunoglobulin M chain 165 68 1.55E-06
IPI00410714 Alpha 2 globin variant 433 244 3.33E-06
IPI00163446 The Human Immunoglobulin Heavy Diversity (IGHD) 134 53 4.03E-06
IPI00171834 Keratin, type I cytoskeletal 19 140 57 1.29E-05
IPI00399007 Hypothetical protein DKFZp686I04196 5114 4039 1.41E-05
IPI00003590 Quiescin Q6 15 0 4.53E-05
IPI00022389 Splice Isoform 1 of C-reactive protein precursor 15 0 4.53E-05
IPI00015309 Keratin, type I cytoskeletal 12 89 33 7.63E-05
IPI00290077 Keratin, type I cytoskeletal 15 142 62 8.21E-05
IPI00217963 Keratin, type I cytoskeletal 16 223 117 0.000146102
IPI00418422 The Human Immunoglobulin Heavy Diversity (IGHD) 69 23 0.000152193
IPI00423461 Hypothetical protein DKFZp686C02220 828 548 0.000223242
IPI00450768 Keratin, type I cytoskeletal 17 147 69 0.000275352
IPI00011261 Complement component C8 gamma chain precursor 266 152 0.000391696
IPI00556567 Ficolin-3 protein 80 33 0.000819734
IPI00441196 Hypothetical protein 3090 2450 0.000949718
IPI00386839 Amyloid lambda 6 light chain variable region SAR 180 98 0.001229635
IPI00017601 Ceruloplasmin precursor 2260 1816 0.001476612
IPI00383953 VH4 heavy chain variable region precursor 132 64 0.001483067
IPI00009866 Keratin, type I cytoskeletal 13 107 52 0.001918932
IPI00470798 Hypothetical protein DKFZp686E23209 4508 3647 0.002098573
IPI00017530 Ficolin-2 precursor 9 0 0.002266054
IPI00021854 Apolipoprotein A-II precursor 853 582 0.002359293
IPI00004550 Hypothetical protein FLJ20261 96 45 0.00238822
IPI00011252 Complement component C8 alpha chain precursor 81 36 0.002415224
IPI00293898 Hepatocellular carcinoma associated protein TB6 19 4 0.002727717
IPI00384444 Keratin, type I cytoskeletal 14 207 120 0.003122976
IPI00021856 Apolipoprotein C-II precursor 32 11 0.00418406
IPI00219806 S100 calcium-binding protein A7 8 0 0.004391148
IPI00446354 Hypothetical protein FLJ41805 8 0 0.004391148
IPI00479762 115 kDa protein 8 0 0.004391148
IPI00022446 Platelet factor 4 precursor 82 39 0.00501026
IPI00300725 Keratin, type II cytoskeletal 6A 158 90 0.005161139
IPI00242956 Fc fragment of IgG binding protein 24 8 0.006549075
IPI00384401 Myosin-reactive immunoglobulin kappa chain variable region 25 8 0.006595492
IPI00293665 Keratin, type II cytoskeletal 6B 141 79 0.00706398
IPI00299145 Keratin, type II cytoskeletal 6E 144 83 0.007903541
IPI00383603 Anti-thyroglobulin light chain variable region 7 0 0.008537501
IPI00452748 Serum amyloid A protein precursor 7 0 0.008537501
IPI00021304 Keratin, type II cytoskeletal 2 epidermal 810 575 0.009876282