Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Tetrameric human mitochondrial ALDH structure (left) with the chemical groups represented through a quantum mechanical potential (right). Here, the oxyanion thiohemiacetal intermediate is stabilized by hydrogen bonding from the Asn169 side chain and the Cys302 main chain amide while the hydride is poised to transfer to the C4 of NAD+. Umbrella sampling along a hydride transfer reaction coordinate from this structure led to formation of the adduct.
