Figure 2.
S6c (100 nM) desensitization augments ETA receptor blockade of ET-1-induced contraction in veins but not arteries. ET-1-induced contraction of aorta (a) and vena cava (b) incubated with vehicle, atrasentan (10 nM), S6c (100 nM), or S6c (100 nM) plus atrasentan (10 nM). Data are represented as means ± S.E.M. for the number (N) of animals in parentheses. S6c, sarafotoxin 6c.