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Growth properties of NLS-LMW FGF-2 chimeric proteins in 1% serum. (A) Growth curves of two representative clones. (B) Inverse correlation between NLS-LMW FGF-2 expression and doubling time in low serum. The doubling time of two clones expressing a nuclear-targeted β-galactosidase is also presented. Each point represents the doubling time and FGF-2 expression level of a distinct clone of the type indicated. Doubling times were calculated from growth curves in 1% serum over 6 d.
