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Two step model for IL-1β secretion, showing vesicle-mediated transport from the cytosol to the extracellular space. The translocation step is blocked by glibenclamide and when the ΔpH between cytosol and vesicles is abolished; the exocytosis is induced by high extracellular ATP and by hypotonic medium, whereas it is inhibited by low extracellular ATP and by hypertonic conditions.
