Table 2.
Differentially expressed genes in glaucomatous astrocytes*
| Gene | Description | FC | p-value | CL |
| Genes associated with myosin regulation | ||||
| CALM1 | Calmodulin 1 | 2.23† | 0.00121 | 14q24-q31 |
| MYH10 | Myosin, heavy chain 2 | 1.64 | 0.00588 | 17p13.1 |
| MYLK | Myosin, light polypeptide kinase | 2.89 | 0.000133 | 3q21 |
| PIK3R1 | Phosphoinositide-3-kinase, subunit (p85-alpha) | 1.62 | 0.00201 | 5q13.1 |
| MYPT1 | Protein phosphatase 1, regulator subunit 12A (PPP1R12A) | 1.51 | 0.000775 | 12q15-q21 |
| RAC2 | Ras-related 2 (Rho family, Rac2) | 2.34 | 0.001059 | 22q13.1 |
| RPS6KA3 | Ribosomal protein S6 kinase, 90 kDa, polypeptide 3 | 1.5 | 0.000061 | Xp22.2-p22.1 |
| Genes associated with actin regulation | ||||
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 1.71 | 0.000064 | 13q34 |
| NCK1 | NCK adaptor protein 1 | 1.64† | 0.000015 | 3q21 |
| PDLIM1 | PDZ and LIM domain 1 (elfin, CLP36) | 1.61 | 0.00106 | 10q22-q26.3 |
| PIK3R1 | Phosphoinositide-3-kinase, regulatory subunit 1 | 1.61 | 0.002012 | 5q13.1 |
| PLEC1 | Plectin 1, intermediate filament binding protein | -1.82 | 0.00199 | 8q24 |
| PTPN11 | Protein tyrosine phosphatase, non-receptor type 11 | -1.9 | 0.000005 | 12q24 |
| RAC2 | Ras-related 2 (Rho family, Rac2) | 2.34 | 0.001059 | 22q13.1 |
| SMAD3 | SMAD, mothers against DPP homolog 3 | 1.9 | 0.000488 | 15q22.33 |
| TGFBR1 | Transforming growth factor, beta receptor I | -1.57 | 0.000038 | 9q22 |
| TGFBR2 | Transforming growth factor, beta receptor II | 2.11 | 0.007253 | 3p22 |
| Genes associated with protein trafficking | ||||
| APPBP1 | Amyloid beta precursor protein binding protein 1 | 1.62 | 0.001688 | 16q22 |
| CCL5 | Chemokine (C-C motif) ligand 5 | -1.74 | 0.002283 | 17q11.2-q12 |
| CDH2 | Cadherin 2, type 1, N-cadherin (neuronal) | 1.55 | 0.003173 | 18q11.2 |
| COL4A4 | Collagen, type IV, alpha 4 | 1.59 | 0.002335 | 2q35-q37 |
| CTNNB1 | Catenin (cadherin-associated protein), beta 1, 88 kDa | 2.14 | 0.005445 | 3p21 |
| CTNND1 | Catenin (cadherin-associated protein), delta 1 | 1.68 | 0.000025 | 11q11 |
| GOLGA1 | Golgi autoantigen, golgin subfamily a, 1 | 1.51 | 0.00002 | 9q33.3 |
| GOLGA2 | Golgi autoantigen, golgin subfamily a, 2 | 1.77 | 0.000002 | 9q34.11 |
| GOLGA3 | Golgi autoantigen, golgin subfamily a, 3 | 1.97 | 0.000128 | 12q24.33 |
| HAPLN1 | Hyaluronan and proteoglycan link protein 1 | 8.04 | 0.001193 | 5q14.3 |
| PRSS3 | Protease, serine, 3 (mesotrypsin) | 2.53 | 0.005135 | 9p11.2 |
| RAB1A | RAB1A, member RAS oncogene family | 1.51 | 0.000274 | 2p14 |
| RAB4A | RAB4A, member RAS oncogene family | 1.52 | 0.00035 | 1q42-q43 |
| RAB5B | RAB5B, member RAS oncogene family | 1.5‡ | 0.0081 | 12q13 |
| RAB9A | RAB9A, member RAS oncogene family | 1.64 | 0.000256 | Xp22.2 |
| RAB9P40 | RAB9 effector protein with kelch motifs | 1.84 | 0.000002 | 9q33.3 |
| RABGGTB | Rab geranylgeranyltransferase, beta subunit | 1.76 | 0.000375 | 1p31 |
| TGM2 | Transglutaminase 2 | 2.75 | 0.008289 | 20q12 |
| VCAN | Versican (chondroitin sulfate proteoglycan 2, CSPG2) | 2.94 | 0.000265 | 5q14.3 |
*Genes differentially expressed in AAG compared to CAG (Additional data file 7) except where noted. †From Additional data file 5. ‡From qRT-PCR data (Figure 3b). FC, fold change; CL, chromosome location.