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. 2008 Jul 9;24(18):2037–2043. doi: 10.1093/bioinformatics/btn350

Table 1.

Optimization performance

Optimizer Deviation Correct pars. Fun. calls Limits
Levenberg–Marquardt 1.0994 13/13 598 107
Trust region 1.0995 13/13 2184 107
Simulated annealing 12.62 12/13 10 323 400
Direct search 165807 5/13 7651 100
Genetic algorithm 188 3/13 40 000 103

Deviation of 1 corresponds to a perfect fit. Correctly determined parameters have a deviation below 30%. The required function calls are proportional to the fitting time. Limits around the true value are used during calibration stressing the high performance of the Levenberg–Marquardt and trust region optimizers.