Table 2.
Compounds | OCL formation inhibitory action (IC50)
|
|
---|---|---|
10−9M 1α,25-(OH)2D3 in MVNP-transduced CFU-GM cultures | 10−8M 1α,25-(OH)2D3 in mouse bone marrow cultures | |
TEI-9647 | 7.5 × 10−9M | 1.5 × 10−7M |
(23S,25S)-DLAM-1P | 2.1 × 10−7M | 1.8 × 10−7M |
(23S,25R)-DLAM-1P | 8.6 × 10−7M | 5.0 × 10−7M |
(23S,25S)-DLAM-2P | 4.0 × 10−8M | 1.5 × 10−8M |
(23S,25R)-DLAM-2P | 3.9 × 10−7M | 4.4 × 10−8M |
The IC50 values for the OCL formation inhibitory action of 1α,25-(OH)2D3- 26,23-lactam were calculated from the results in Figure 4.