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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: J Steroid Biochem Mol Biol. 2008 Apr 22;110(3-5):269–277. doi: 10.1016/j.jsbmb.2007.11.007

Table 2.

Comparison of the OCL formation inhibitory actions of 1α,25-(OH)2D3-26,23-lactam analogues between human MVNP-transduced CFU-GM cultures and mouse bone marrow cultures.

Compounds OCL formation inhibitory action (IC50)
10−9M 1α,25-(OH)2D3 in MVNP-transduced CFU-GM cultures 10−8M 1α,25-(OH)2D3 in mouse bone marrow cultures
TEI-9647 7.5 × 10−9M 1.5 × 10−7M
(23S,25S)-DLAM-1P 2.1 × 10−7M 1.8 × 10−7M
(23S,25R)-DLAM-1P 8.6 × 10−7M 5.0 × 10−7M
(23S,25S)-DLAM-2P 4.0 × 10−8M 1.5 × 10−8M
(23S,25R)-DLAM-2P 3.9 × 10−7M 4.4 × 10−8M

The IC50 values for the OCL formation inhibitory action of 1α,25-(OH)2D3- 26,23-lactam were calculated from the results in Figure 4.