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. Author manuscript; available in PMC: 2009 Sep 1.
Published in final edited form as: Cancer Res. 2008 Sep 1;68(17):6884–6888. doi: 10.1158/0008-5472.CAN-08-1101

Figure 1. FTKs enhance the production of ROS and DSBs.

Figure 1

Results in BCR/ABL (B/A), TEL/ABL (T/A), TEL/JAK2), and TEL/PDGFβR (T/P) – transformed cells were compared with results in G418-resistant control cells (P). Results in Lin−CD34+ CML CP and BC cells were compared with Lin−CD34+ peripheral blood cells isolated from healthy volunteers (H). (A) ROS levels were measured by fluorescence. (B,C) γ-H2AX nuclear foci were detected by immunofluorescence; the numbers indicate (B) the percentage of cells with 4–20 and >20 γ-H2AX foci/cell and (C) the mean number of foci/nucleus in cells containing ≥ 4 foci. (D) Representative nuclei containing γ-H2AX foci; nuclei borders are marked in blue. p<0.05 in comparison to other groups (*) and to BC (**).