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Dissociation constants (Kd) for the interaction of the recombinant fibrinogen (Bβ1-66)2 fragment and its mutant variants with the fibrinogen-derived D1 fragment and fibrin-derived D-D fragment obtained by surface plasmon resonancea
| Recombinant Fragments | Kd for interaction with D-D (μM) | Kd for interaction with D1 (μM) |
|---|---|---|
| (Bβ1-66)2 | 13.0 ± 2.0 | 153 ± 16 |
| Mut-(Bβ1-66) 2 | 14.8 ± 3.7 | 148 ± 21 |
| Mut-(β18-66)2 | 14.0 ± 0.6 | --- |
Values are the means ± S.D. of at least three independent experiments.
