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. 1998 Apr;9(4):875–884. doi: 10.1091/mbc.9.4.875

Figure 7.

Figure 7

Inhibition of the HMC-1- and VEGF-induced HMVEC proliferation with a neutralizing VEGF-specific antibody. (A) The mitogenic effects of VEGF (10 ng/ml) and of 100% CM were suppressed up to 100% and 90%, respectively, in the presence of a neutralizing VEGF-specific mAb or up to 75% by a preincubation of the CM with heparin-conjugated agarose beads. Data are expressed as percentage of stimulation of HMVEC proliferation in comparison to control medium. (B) This Figure demonstrates the VEGF-specific mAb-induced dose-dependent neutralization of the mitogenic effect of CM. The antibody used showed its half-maximal inhibitory effect at a concentration of 25 ng/ml. A control antibody showed no inhibitory effect. In both figures mean values ± SD from three separate experiments are shown.