Cnm67p coiled-coil prediction, tetrad analysis,
and complementation test. (A) Probability plot for coiled-coil
formation of the 581 amino-acid sequence of Cnm67p. The central part of
the protein was predicted to contain three α helical coiled-coil
regions (residues 174–226, p = 1; residues 306–357, p = 1;
residues 382–448, p = 0.924) by the Paircoil program (Berger
et al., 1995). The CNM67 sequence is
available from EMBL/GenBank/DDBJ under accession number Z71501. (B)
Tetrad dissection of a heterozygous CNM67-deleted strain
(ABY101). Tetrad colonies were transferred on G418 containing medium to
test for segregation of the kanMX4 gene deletion marker.
Slow growing colonies always carried the
cnm67::kanMX4 allele
(cnm67Δ1). (C) Complementation of the
cnm67Δ1 growth defect by transformation with a plasmid
carrying the CNM67 wild-type allele.