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. Author manuscript; available in PMC: 2008 Sep 8.
Published in final edited form as: J Am Chem Soc. 2006 Dec 20;128(50):15948–15949. doi: 10.1021/ja065303t

Figure 1.

Figure 1

(A) The backbone A-to-E mutation eliminates a H-bond donor and weakens the acceptor; The A-to-O mutation eliminates both the H-bond donor and acceptor. (B) The backbone amide perturbation strategy in the Pin WW domain, wherein a H-bond donor is removed using both A-to-E and A-to-O mutations. (C) Structure of the Phe-Phe dipeptide derivatives designed to evaluate the desolvation energy differences between the amide, ester and E-olefin derivatives. PEG fragments were appended to increase water solubility.