Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Hypothetical model of the binding of 22-hydroxyacuminatine (2b) in the Top1-DNA-inhibitor ternary complex. The cleaved DNA strand is on the left, while the uncleaved strand is on the right. The DNA minor groove side is facing forward, while the major groove is on the back. The model is programmed for walleyed (relaxed) viewing.
