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. Author manuscript; available in PMC: 2008 Sep 8.
Published in final edited form as: Biochemistry. 2005 Aug 30;44(34):11329–11341. doi: 10.1021/bi0501840

Figure 6.

Figure 6

A. Superposition of receptor-bound conformation of inverse agonist AGRP (87-132) (yellow) inside the model of hMC4R in the inactive state, and peptide agonist, NDP-MSH (purple) inside the model of hMC4R in the active state; B. Superposition of receptor-bound conformations of peptide agonist NDP-MSH (purple) and small-molecule agonist THIQ (green) inside the model of hMC4R in the active state. Core residues of AGRP (Arg111, Phe112, Phe113) and of NDP-MSH (His6, D-Phe7, Arg8, Trp9) are shown in the licorice representation.