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Putative arrangement of the N-terminal fragment (15-27) inside the binding pocket of hMC4R, docked similarly to the peptide agonistα-MSH (1-13). The N-terminal fragment is shown in the licorice representation colored by element,α-MSH is shown by a thin purple line. The central tetrapeptide fragment of the N-terminal sequence 20SYRL structurally overlaps with 6HFRW of the peptide agonist,α-MSH.
