Table 2.
The dihedral angles (°) for calculated receptor bound conformations of fragments 2-12 of α-MSH and NDP-MSH.
| Dihedral angles |
Residues |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Tyr2 | Ser3 | Met4/ Nle4 |
Glu5 | His6 | LPhe7/ DPhe7 |
Arg8 | Trp9 | Gly10 | Lys11 | Pro12 | |
| α-MSH | |||||||||||
| ω | 178 | 175 | 179 | -176 | 171 | -174 | 172 | 173 | 177 | 168 | -179 |
| φ | -96 | -170 | -155 | -83 | -55 | 89 | -67 | -131 | -163 | -121 | -74 |
| ψ | 106 | 105 | 159 | -172 | 131 | 129 | 88 | 65 | -144 | 78 | 127 |
| Χ1 | 173 | 175 | -34 | -62 | -76 | -159 | -63 | -78 | -174 | ||
| Χ2 | 109 | -145 | 81 | -159 | 135 | -67 | 130 | -178 | |||
| Χ3 | -76 | -92 | 143 | -169 | |||||||
| Χ4 | -179 | 66 | |||||||||
| NDP-MSH | |||||||||||
| ω | 178 | 169 | -175 | -170 | 174 | 178 | 177 | 169 | 173 | 176 | -179 |
| φ | -174 | -170 | -155 | -103 | -73 | 157 | 60 | -92 | -162 | -156 | -63 |
| ψ | 125 | 114 | 153 | -170 | 86 | -22 | 52 | 88 | -107 | 74 | 122 |
| Χ1 | -166 | 178 | -73 | -73 | -80 | 159 | -55 | -60 | -175 | ||
| Χ2 | 80 | -177 | 102 | -114 | 99 | -57 | 110 | 173 | |||
| Χ3 | -72 | -63 | 177 | -179 | |||||||
| Χ4 | 121 | 70 | |||||||||
α-MSH, Ac-Ser1-Tyr2-Ser3-Met4-Glu5-His6-Phe7-Arg8-Trp9-Gly10-Lys11-Pro12-Val13-NH2
NDP-MSH, [Nle4, -Phe7-]α-MSH