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. 2008 Aug 22;8:3. doi: 10.1186/1472-6769-8-3

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Copyright © 2008 Warringer et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Drug-drug interactions in different physiological windows. Interactions within a mini-array of multi-replicated (n = 50 for single compounds, n = 20 for compound combinations) bioactive compounds. A) Multiplicative model of synthetic chemical interactions. B) Overview of all drug-drug interactions. Dashed line indicates null interaction, i.e. 1:1 correlation between observed (LEC_xy) and expected (LEC_x+ LEC_y) effects. C-E) Heatmap of drug-drug interactions depicted as observed (LEC_xy) – expected (LEC_x+ LEC_y) effects. Red = alleviation, green = aggravation.