Figure 6.

Effects of Kihi-to on Aβ(25–35)-induced decreases of myelin. Aβ(25–35) (25 nmol) was injected into the right lateral ventricle of mice. From ten days after the injection, mice were administered vehicle (V, water by p.o.; DMSO by i.v.) or Kihi-to (K, 100 mg/kg B.W., p.o.) for 3 days. The control mice (C) were injected with a reverse peptide, Aβ(35–25) and then administered vehicle. After the novel object recognition test (Figure 2), brain slices were immunostained with myelin basic protein (MBP) antibody. MBP-positive areas were quantified in the striatum, corpus callosum, and the parietal, perirhinal and frontal cortex. *p < 0.05 vs. Veh. n = 3. (one-way ANOVA followed by Holm-Sidak post hoc test).