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. 2008 Aug 6;36(16):5250–5259. doi: 10.1093/nar/gkn506

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© 2008 The Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — GeneChip analysis for responsive gene modulated by transcription factor TAF1. (A) Experimental conditions of the GeneChip analysis. 1: Cells transfected with scramble siRNA; 2: cells transfected with scramble siRNA and treated with H₂O₂; 3: cells transfected with TAF1 siRNA; 4: cells transfected with TAF1 siRNA and treated with H₂O₂. Cell lysates were subjected to immunoblot analysis with indicated antibodies. (B) Hierarchical clustering depicting expression profiles of differentially regulated genes by depletion of TAF1 gene. The data indicate the means from three independent experiments, each performed in triplicate. 1 versus 3, the value for the expression level of condition 1 divided by that of condition 3; 2 versus 4, the value for the expression level of condition 2 divided by that of condition 4. Up- and down-regulated genes are depicted in red and blue, respectively. (C) The number of GeneChip probes more than 1.5-fold up- or down-regulated by knocking down TAF1 is indicated.