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Interstrand crosslinking by mechlorethamine. The monofunctional lesion (top) which has a cationic purine and a cationic sidechain distorts the DNA so the 5′-GNC crosslink forms in favor of the predicted 5′-GC lesion (middle). The distance of the 5′-GNC crosslink is ~ 1.5 A longer than the covalent bridge between the strands; therefore the DNA must be distorted (bottom).
