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. Author manuscript; available in PMC: 2008 Sep 9.
Published in final edited form as: Biomacromolecules. 2006 Sep;7(9):2565–2574. doi: 10.1021/bm060361s

Table 2.

Decomposition parameters of the water-soluble diazeniumdiolated polymers.

Compound aqueous media kD (×10−5 s−1) t1/2a,c (min)
HMwPEI/NO (5) 100 mM phosphate buffer 6.0 192.0 ± 1.7
HMwPEI/NO (5) PAANa solution b 16.1 72.0 ± 3.0
PEI-COONa/NO (8) 100 mM phosphate buffer 19.4 59.4 ± 0.8
PEI-PRO/NO (11) 100 mM phosphate buffer 24.1 48.0 ± 2.5
a

measured at 37 °C via the CL NOA;

b

1 mg/mL of sodium salt of poly(acrylic acid) in 100 mM phosphate buffer (pH 7.4);

c

Mean ± SD (n ≥ 3).