Table 4.
Univariate analysis of factors influencing AUC for T-cell subset immune reconstitution
| Factor |
P (by 2-tailed t test between mean AUCs) |
|||||
|---|---|---|---|---|---|---|
| CD4+ T cells |
CD8+ T cells |
|||||
| 4 m | 6 m | 12 m | 4 m | 6 m | 12 m | |
| Age (below median vs above) | .02* | .19 | .05 | .05 | .13 | .17 |
| Diagnosis (malignancy vs BMF) | .76 | .54 | .56 | .68 | .70 | .77 |
| CD34+ cell dose (above median vs not above) | .59 | .82 | .47 | .84 | .71 | .86 |
| CD4+ or CD8+ T-cell dose (above median vs not above) | .32 | .58 | .74 | .19 | .08 | .16 |
| aGvHD (grades B-D vs less than grade B)† | .26 | .94 | .39 | .50 | .54 | .63 |
| CMV (reactivation vs no reactivation)‡ | .43 | .64 | .88 | .08 | .06 | .005* |
AUC indicates area under curve; other abbreviations as in Table 1.
Statistically significant.
Grade B-D aGVHD (n = 3) versus less than grade B aGVHD (n = 5).
CMV reactivation (n = 3) versus no CMV reactivation (n = 5).