Table 2.
Median pharmacokinetic parameters of GCV following dosing with IV Ganciclovir (GCV), Valganciclovir (VGCV) and oral Ganciclovir (GCV)
| Parameter | IV GCV * n = 6 | VGCV 900 mg * n = 6 | VGCV 450 mg n = 7 | Oral GCV N = 7 |
|---|---|---|---|---|
| AUC0–24 (μg/h/mL) | 60.631 (47.24–85.35) | 62.861 (47.273–77.413) | 35.896 (27.986–43.386) | 29.041 (15.18–51.30) |
| Cmax (μg/mL) | 6.824 (6.465–7.768) | 7.972 (3.814–13.798) | 4.146 (3.063–4.678) | 1.435 (0.788–2.614) |
| Cmin (μg/mL) | 0.864 (0.641–2.024) | 0.545 (0.322–1.003) | 0.255 (0.171–0.804) | 0.759 (0.385–1.528) |
| Tmax (h) | 1 (1–1.5) | 1.75 (1–2) | 2 (1–6) | 2 (1.5–4) |
| F (%) | 34 | 6 |
Medians with range in parentheses.
*
One patient was excluded from the analysis when it was discovered that they did not take their VGCV dose on the morning of pharmacokinetic sampling. The missing patient’s measured values for AUC0–24, Cmax, Cmin, Tmax, were 128.519 μg/h/ml, 11.623 μg/mL, 2.902 μg/mL, 1 h respectively for IV GCV and 12.635 μg/h/mL, 1.701 μg/mL, 0.147 μg/mL, 0 h, 8.1 h, respectively, for VGCV 900 mg.