Table 4.

Seizure-induced changes in NMDA and AMPA receptor subunit expression in rat and human dentate gyrus granule cells.

					Pilocarpine					Kindling
	Kainic Acid				Early	Early	Late	Early	Late	ptz	Elec.	ECS		SSLSE	TLE
	1	2	3	4	1	3		5		6	7	8	9	10	11	12	13
NMDA
NR1	—		—	—					—				—			—	—
NR2A								—	—				—
NR2B									—				—
NR2C													—
NR2D													—
AMPA
GluR1	—			—				—	—	flop	flip
GluR2		flip	flip		—	flip flop		—		flip	flip				(2/3)	(2/4)
GluR3											flip				(2/3)
GluR4																(2/4)

References for Table 4 (each column represents a different study): 1) Condorelli and others (1994); 2) Pollard and others (1993); 3) Lason and others (1997); 4) Friedman and others (1994); 5) Mathern and others (1998b); 6) Lason and others (1998); 7) Kamphuis and others (1994); 8) Watkins and others (1998); 9) Naylor and others (1996); 10) Mathern and others (1998a); 11) Mathern and others (1998c, 1999); 12) Blumcke and others (1996); 13) Musshoff and others (2000).

Abbreviations: = increased relative to control; = decreased; — = no change; PTZ = pentylenetetrazol; elec. = electrical kindling of the Schaffer collaterals in the hippocampus; ECS = electroconvulsive shock; SSLSE = self-sustaining limbic status epilepticus; TLE = human temporal lobe epileptic specimens. Other methods used to examined changes were often different. Latencies after seizures also differed across studies, making exact comparisons difficult. (Flip) or (flop) refer to flip or flop splice variants of the particular GluR subunit in question. Data from three pilocarpine studies are shown, one that examined only early times (within a few days) after status and others that examined early or late (weeks or months after status) times after status. “(2/3)” or “(2/4)” refers to data using a label that did not discriminate well between subunits 2 and 3 or 2 and 4; note that the 2/4 data are primarily from the molecular layer, not the granule cell layer.