Table 5.
Seizure-induced changes in GABA receptor subunit expression in rat and human dentate gyrus granule cells.
| Kainic Acid | Pilocarpine | Kindling | ECS | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Early | Late | Early | Late | Late | Early | Late | Early | Late | Early | TLE | ||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |||||
| GABAA | ||||||||||||
| K | ||||||||||||
| 1 |
|
|
|
|
|
— |
|
|
— |
|
— | |
| 2 |
|
* |
— | — |
|
— |
|
|||||
| 3 |
|
** |
|
— |
|
— | (
) |
|||||
| 4 |
|
|
|
|
|
— |
|
|||||
| 5 |
|
|
— | — |
|
— | ||||||
| 6 |
|
— | ||||||||||
| 2 | ||||||||||||
| 1 |
|
|
|
|
|
— |
|
|||||
| 2 |
|
|
— | — |
|
— |
(2/3) |
|
||||
| 3 |
|
|
|
|
|
|
|
— | — |
(2/3) |
|
|
| 3 | ||||||||||||
| 1 | — | — | — | — | ||||||||
| 2 |
|
|
— | — |
|
|
|
|
— |
|
|
|
| 3 | — | — | ||||||||||
| L |
|
|
|
|
||||||||
| M |
|
|
||||||||||
References for Table 5 (each column represents a different study): 1) Tsunashima and others (1997); Sperk and others (1998); 2) Brooks-Kayal and others (1998); 3) Fritschy and others (1999); 4) Kamphuis and others (1994); 5) Kokaia and others (1994); 6) Clark (1998); 7) Loup and others (2000); 8) Sperk and others (personal communication).
Abbreviations:
= increased relative to control;
= decreased; — = no change, (
) = small increase that was not significant. Note methods used to examined changes were often different. Latencies after seizures also differed across studies, making exact comparisons difficult.
* = increase in protein but not mRNA,
** = increase in mRNA but not protein. Only data for the granule cells or granule cell layer are listed, except for human studies, which sometimes examined the dentate molecular layer but not the granule cell layer. “(2/3)” refers to results that did not discriminate between β2 or β3. For kainic acid and pilocarpine studies, early = within hours of status epilepticus, late = weeks after kainic acid or pilocarpine-induced status epilepticus. For kindling studies, early and late refer to 1 versus 28 days after the last kindled seizure (Kamphuis and others 1995) or 4 versus 12-48 h after the last of 40 kindled seizures (Kokaia and others 1994).