Fig 3.

Average change in proliferation signature genes upon transformation and occurrence of genomic aberrations in each transformed follicular lymphoma (t-FL) sample. For 20 genes, comprising the proliferation signature, the change in expression between follicular lymphoma and t-FL was calculated for each sample pair. The average log change was then determined for all clones in each pair. Black squares indicate the presence of either TP53 mutation, loss of heterozygosity and the TP53 locus, CDKN2A loss or c-REL amplification. Clear boxes represent wild type configuration.