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. Author manuscript; available in PMC: 2008 Dec 27.
Published in final edited form as: J Med Chem. 2007 Dec 4;50(26):6673–6684. doi: 10.1021/jm070685e

Scheme 1.

Scheme 1

Preparation of 2-fluoroethoxy derivativesa

aReagents and conditions: (a) 1) NaNO2, 2) KS2COEt, 3) HCl; (b) Na/EtOH, (c) 1) SOCl2, 2) (CH3)2NH, CHCl3; (d)1.0 M BBr3 in DCM, MW, 100 °C or − 78°C - rt, 8h; (e) 1-bromo-2-fluoroethane, DMF, K2CO3, MW; (f) BH3-THF, THF, 4–5 h.