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. Author manuscript; available in PMC: 2008 Dec 27.
Published in final edited form as: J Med Chem. 2007 Dec 4;50(26):6673–6684. doi: 10.1021/jm070685e

Scheme 2.

Scheme 2

Preparation of 3-fluoropropoxy derivativesa

aReagents and conditions: (a) 3-bromo-1-propanol, K2CO3, DMF, MW, 15 min; (b) MsCl, TEA, DCM, 1 h; (c) TBAF, THF, MW, 20 min; (d) BH3-THF.THF, 4–5 h; (e) DAST, DCM, −78 °C - rt, 1 h.