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. Author manuscript; available in PMC: 2008 Dec 27.
Published in final edited form as: J Med Chem. 2007 Dec 4;50(26):6673–6684. doi: 10.1021/jm070685e

Scheme 3.

Scheme 3

Preparation of 4′-methoxy, 4′-hydroxy, 4′-(2-hydroxyethoxy)- and 4′-(3-hydroxypropoxy)- derivativesa

aReagents and conditions: (a) BH3-THF.THF, 4–5 h; (b) 2-bromo-1-ethanol, K2CO3, DMF, MW, 150°C, 15 min.