Table 2.

Biodistribution of [¹⁸F] labeled SERT tracers were evaluated in rats after an iv injection. Brain uptake (% dose/organ), hypothalamus uptake (% dose/g), and hypothalamus to cerebellum ratio are shown.

Brain uptake (% dose/organ)
Compound	30 min	120 min
28	1.85 ± 0.15	0.63 ± 0.15
29	2.23 ± 0.22	2.57 ± 0.18
30	1.72 ± 0.35	1.46 ± 0.16
31	1.88 ± 0.18	2.16 ± 0.14
40	1.23 ± 0.18	0.59 ± 0.10
41	1.43 ± 0.06	1.32 ± 0.01
42	1.12 ± 0.06	1.15 ± 0.10
Hypothalamus uptake (% dose/g)			Hypothalamus to cerebellum ratio
Compound	30 min	120 min	Compound	30 min	120 min
28	1.62 ± 0.10	0.74 ± 0.18	28	3.79 ± 0.30	7.83 ± 2.96
29	1.76 ± 0.16	2.22 ± 0.28	29	2.78 ± 0.32	4.34 ± 0.60
30	1.31 ± 0.28	1.19 ± 0.11	30	2.36 ± 0.68	3.77 ± 0.40
31	1.19 ± 0.10	1.78 ± 0.24	31	2.04 ± 0.07	3.70 ± 0.58
40	1.22 ± 0.16	0.75 ± 0.18	40	3.50 ± 0.67	7.67 ± 2.60
41	1.05 ± 0.12	1.09 ± 0.09	41	2.66 ± 0.56	4.36 ± 0.45
42	0.85 ± 0.08	1.01 ± 0.21	42	1.93 ± 0.82	4.17 ± 0.48