Fig. 3.

Mavs^−/− and DKO mice are able to clear RSV and resolve pulmonary disease. (A and B) WT, Myd88^−/−, Mavs^−/−, and Myd88^−/−Mavs^−/− (DKO) mice were infected with RSV (10⁷ pfu) and BALF was harvested at the indicated times to measure viral loads by plaque assay. (A: *, mavs^−/− vs. myd88^−/−, P < 0.001; **, mavs^−/− vs. DKO and mavs^−/− vs. myd88^−/−, P < 0.001; B: *, mavs^−/− vs. DKO and mavs^−/− vs. myd88^−/−, P < 0.01; ANOVA) (n = 3–5). (C) Lungs from infected mice and mock controls were analyzed by immunohistochemistry using a polyclonal anti-RSV antibody. (D) Mice infected with RSV were assessed by whole-body plethysmography to measure airway obstruction (*, P < 0.0001; **, P < 0.03; ***, P < 0.04; ANOVA). n.d., not detected; Penh, enhanced pause. Data are represented as mean ± SEM.