Table 1. Animal physiological variables.
|
After streptozotocin induction of diabetes |
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|
Baseline (n=4) |
5 days (n=4 |
10 Days (n=4) |
15 Days (n=4) |
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|
sample |
BW (g) |
Blood sugar (mg/dl) |
BW (g) |
Increase in body weight (%) |
Blood sugar (mg/dl) |
BW (g) |
Increase in body weight (%) |
Blood sugar (mg/dl) |
BW (g) |
Increase in body weight (%) |
Blood sugar (mg/dl) |
| Age-matched control rat |
248+14 |
139+13 |
260+13 |
4.8 |
141+11 |
294+10 |
18.5 |
154+12 |
312+9 |
25.8 |
143+11 |
| STZ-induced diabetic rat | 254+11 | 143+9 | 257+10 | 2.4 | 352+15 | 270+14 | 7.7 | 377+13 | 280+11 | 11.6 | 396+15 |
Animals were made diabetic by a single streptozocin (STZ) injection (65 mg/kg) in 1 mmol/l sodium citrate buffer, pH 4.5. All diabetic animals had higher blood glucose levels and reduced body weight gain compared to age matched, non-diabetic control animals.