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Properties of superfunctional MccJ25 derivative [Gly15]MccJ25
| MccJ25 derivative | Inhibition of RNAP (IC50)a |
|---|---|
| μm | |
| MccJ25 | 2.5 |
| [Gly15]MccJ25 | 2.5 |
|
MccJ25 derivative
|
Inhibition of bacterial growth (inhibition zone
diameter)b
|
||
|---|---|---|---|
| E. coli DH5α | S. flexneri BK 12440 | ||
| mm | |||
| MccJ25 | 3 ± 1 | 8 ± 1.5 | |
| [Gly15]MccJ25 | 9 ± 1 | 13 ± 1.7 | |
IC50 is the concentration of MccJ25 derivative resulting in 50% inhibition of RNAP.
Mean results of three independent measurements with S.D. values are presented.
