MAGP-1 deficiency leads to increased body size and fat deposition.
A, side-by-side comparison of representative wild-type
(left) and MAGP-1-/- (right) mixed strain mice
demonstrates that MAGP-1-/- mice are larger than age-matched
wild-types. B, graph showing that BSw MAGP-1-/- male mice
have significantly higher body weight at 3 months of age than age-matched BSw
wild-type animals. *, p < 0.01 for wild-type
versus MAGP-1-/-; error bars indicate mean
± S.E. (n = 34). C, BSw MAGP-1-/- mice
have increased fat deposition relative to wild-types. Epididymal fat pads were
harvested from 3- and 6-month-old BSw male mice. Fat pad ratio was calculated
as fat pad weight (g) divided by body weight (BW, g) and expressed as
a percentage. * and ** indicate p < 0.02 and
p < 1 × 10-6, respectively, for wild-type
versus MAGP-1-/-; error bars indicate mean
± S.E. (n = 38).