FIGURE 8.

MAGP-1 deficiency leads to a delay in the wound healing and prolonged bleeding. A, excisional wounds 6 mm in diameter were made on the dorsum of 3-month-old BSw male mice. Healing was followed by calculating wound size as percentage of the original 6-mm wound. ^**, p < 0.01 for wild-type versus MAGP-1^-/-; error bars indicate mean ± S.E. (n = 27). B, MAGP-1 deficiency results in delayed thrombotic occlusion of the carotid artery. Blood flow in the common carotid artery was monitored continuously with an ultrasonic flow probe. Local endothelial injury was induced by application of a 540 nm laser beam to the carotid artery followed by injection of rose Bengal dye into the lateral tail vein. Shown are the times from the onset of injury until the cessation of flow. Tail vein bleeding time was determined by making a transverse incision over a lateral vein and immersing the tail in normal saline (37 °C) in a hand-held test tube. The time from the incision to the cessation of bleeding was recorded as the bleeding time. ^**, p < 0.01 for +/+ versus -/-. Error bars indicate mean ± S.E. (n = 24).