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Overexpression of GRX1 and GRX2 increases resistance to oxidants. Wild-type strains containing pRS426, mcGRX1, pRS424, and mcGRX2 were grown to exponential phase in SD medium and treated with 4 mM H2O2 (A) or 180 mM menadione (B). Cells were diluted and plated in triplicate onto YEPD medium to monitor cell viability at 20-min intervals. Percent survival is expressed relative to the untreated control cultures.
