Table 1.
28 SNPs from IL1A and IL1B were genotyped in 1314 NARAC RA cases and 1103 controls. The allele that is more frequent in cases is shown in bold capital letters and the allele frequency and odds ratio are given for this allele. Genotype counts: (homozygotes of the allele more frequent in cases, heterozygotes, homozygotes of the alternate allele). P-values are from chi-squared analysis performed on the allele counts for single markers in RA patients versus controls.
Allelic Polymorphism in IL1 in Cases vs. Controls: NARAC
| Gene | SNP | SNP Info. | Alleles | Cases Freq (Gen. Cts) | Controls Freq (Gen. Cts) | OR | 95% CI | P value | |
|---|---|---|---|---|---|---|---|---|---|
| IL1A | rs6712572 | intron (CKAP2L) | T/g | 0.51 (332, 652, 296) | 0.50 (282, 536, 276) | 1.04 | 0.93 | 1.17 | 5.0E-01 |
| rs1304037 | 3′ UTR (IL1A) | A/g | 0.73 (686, 506, 92) | 0.70 (546, 444, 105) | 1.16 | 1.02 | 1.32 | 2.1E-02 | |
| rs3783550 | intron (IL1A) | C/a | 0.31 (133, 530, 609) | 0.30 (107, 416, 538) | 1.08 | 0.95 | 1.22 | 2.6E-01 | |
| rs17561 | missense (IL1A) | G/t | 0.73 (686, 513, 87) | 0.70 (545, 443, 104) | 1.17 | 1.03 | 1.33 | 1.5E-02 | |
| rs2856841 | intron (IL1A) | T/c | 0.73 (673, 502, 91) | 0.70 (537, 435, 107) | 1.17 | 1.03 | 1.32 | 1.8E-02 | |
| rs3783531 | missense (IL1A) | A/g | 0.00 (0, 9, 1282) | 0.00 (0, 7, 1089) | 1.09 | 0.41 | 2.94 | 8.6E-01 | |
| rs1609682 | intron (IL1A) | C/a | 0.31 (142, 516, 621) | 0.29 (110, 418, 559) | 1.10 | 0.97 | 1.24 | 1.4E-01 | |
| rs2856837 | intron (IL1A) | C/t | 0.73 (686, 507, 90) | 0.70 (560, 442, 104) | 1.15 | 1.02 | 1.31 | 2.8E-02 | |
| rs1800587 | 5′ UTR (IL1A) | C/t | 0.73 (687, 507, 89) | 0.70 (546, 445, 105) | 1.17 | 1.03 | 1.33 | 1.5E-02 | |
| rs6746923 | 5′ non-gene region | A/g | 0.42 (233, 615, 440) | 0.40 (176, 535, 383) | 1.06 | 0.94 | 1.19 | 3.4E-01 | |
| rs17597976 | 5′ non-gene region | A/g | 0.13 (29, 283, 979) | 0.12 (15, 242, 842) | 1.08 | 0.91 | 1.28 | 4.0E-01 | |
| rs11687624 | 5′ non-gene region | C/t | 0.44 (249, 643, 392) | 0.42 (192, 532, 372) | 1.10 | 0.98 | 1.24 | 9.0E-02 | |
| IL1B | rs4849125 | 3′ non-gene region | A/g | 0.70 (616, 539, 101) | 0.69 (507, 444, 108) | 1.08 | 0.95 | 1.23 | 2.3E-01 |
| rs1143642 | intron (IL1B) | C/t | 0.93 (1106, 171, 4) | 0.92 (922, 163, 10) | 1.22 | 0.98 | 1.51 | 7.5E-02 | |
| rs1143634 | synonomous (IL1B) | G/a | 0.78 (761, 416, 63) | 0.78 (663, 378, 55) | 1.02 | 0.89 | 1.17 | 7.6E-01 | |
| rs1143633 | intron (IL1B) | T/c | 0.37 (159, 580, 485) | 0.37 (154, 493, 445) | 1.00 | 0.89 | 1.13 | 9.4E-01 | |
| RA1 | intron (IL1B) | C/t | 1.00 (1300, 0, 0) | 1.00 (1099, 0, 0) | NA | NA | NA | NA | |
| rs1143627 | 5′ non-gene region | A/g | 0.66 (544, 544, 149) | 0.65 (465, 493, 135) | 1.04 | 0.92 | 1.17 | 5.5E-01 | |
| rs16944 | 5′ non-gene region | G/a | 0.66 (573, 548, 156) | 0.65 (466, 501, 134) | 1.06 | 0.94 | 1.20 | 3.5E-01 | |
| RA2 | 5′ non-gene region | C/t | 1.00 (1236, 0, 0) | 1.00 (1095, 1, 0) | NA | NA | NA | 2.9E-01 | |
| RA3 | 5′ non-gene region | A/g | 0.84 (837, 302, 41) | 0.80 (704,341, 45) | 1.27 | 1.09 | 1.48 | 2.1E-03 | |
| rs13013349 | 5′ non-gene region | G/a | 0.66 (537, 547, 153) | 0.65 (467, 493, 135) | 1.02 | 0.90 | 1.15 | 7.5E-01 | |
| rs13032029 | 5′ non-gene region | T/c | 0.47 (198, 451, 250) | 0.45 (190, 429, 276) | 1.09 | 0.95 | 1.24 | 2.1E-01 | |
| RA4 | 5′ non-gene region | C/g | 0.94 (829, 100, 2) | 0.92 (778, 123, 6) | 1.35 | 1.03 | 1.75 | 2.7E-02 | |
| rs4447608 | 5′ non-gene region | T/c | 0.48 (203, 469, 250) | 0.46 (200, 432, 270) | 1.06 | 0.93 | 1.21 | 3.6E-01 | |
| rs6735739 | 5′ non-gene region | C/t | 0.66 (568, 576, 156) | 0.66 (475, 495, 130) | 1.01 | 0.90 | 1.14 | 8.6E-01 | |
| rs6745746 | 5′ non-gene region | A/g | 0.46 (228, 637,332) | 0.45 (222, 534, 329) | 1.03 | 0.91 | 1.16 | 6.4E-01 | |
| rs12053091 | 5′ non-gene region | C/t | 0.27 (77, 346, 499) | 0.26 (69, 327, 504) | 1.06 | 0.92 | 1.23 | 4.1E-01 | |