Table 3.
24 SNPs from IL1A and IL1B were genotyped in 712 RA patients. A chi-squared analysis was performed comparing IL1 allele counts in the 403 of these patients that had erosions on plain radiographs of the hands versus the 309 that did not. Frequencies and odds ratios are shown for the allele that is capitalized and in bold. Genotype counts: (homozygotes of the allele capitalized and in bold, heterozygotes, homozygotes of the alternate allele). Chi-squared analysis of allele counts was performed for cases versus controls.
Allelic Polymorphism in IL1 in Patients With vs. Without erosions: BRASS Cohort
| Gene | SNP | SNP Info | Alleles | Eros pos. Freq (Gen. Cts.) | Eros neg. Freq (Gen. Cts) | OR | 95% CI | P value | |
|---|---|---|---|---|---|---|---|---|---|
| IL1A | rs6716572 | intron (CKAP2L) | T/g | 0.52 (108, 209, 93) | 0.51 (72, 154, 71) | 1.06 | 0.86 | 1.32 | 5.8E-01 |
| rs3783550 | intron (IL1A) | C/a | 0.28 (34, 160, 203) | 0.28 (24, 115, 153) | 1.01 | 0.79 | 1.25 | 9.6E-01 | |
| rs17561 | missense (IL1A) | G/t | 0.74 (223, 157, 30) | 0.70 (145, 117, 34) | 1.23 | 0.97 | 1.60 | 9.0E-02 | |
| rs3783531 | missense (IL1A) | A/g | 0.00 (0, 3, 406) | 0.00 (0, 3, 293) | 0.70 | 0.10 | 2.83 | 7.2E-01 | |
| rs1894399 | intron (IL1A) | G/a | 0.74 (220, 155, 26) | 0.71 (145, 116, 29) | 1.18 | 0.93 | 1.55 | 1.8E-01 | |
| rs1800587 | 5′ UTR (IL1A) | C/t | 0.74 (222, 158, 30) | 0.70 (146, 118, 34) | 1.21 | 0.95 | 1.57 | 1.2E-01 | |
| rs6746923 | 5′ non-gene region | A/g | 0.45 (80, 200, 127) | 0.40 (50, 136, 110) | 1.20 | 0.96 | 1.49 | 1.0E-01 | |
| rs17597976 | 5′ non-gene region | A/g | 0.14 (4, 104, 294) | 0.13 (7, 61, 226) | 1.12 | 0.81 | 1.46 | 4.9E-01 | |
| IL1B | rs4849125 | 3′ non-gene region | A/g | 0.72 (213, 155, 37) | 0.68 (137, 119, 37) | 1.22 | 0.96 | 1.57 | 1.0E-01 |
| rs7596684 | 3′ non-gene region | T/c | 0.82 (271, 117, 17) | 0.79 (180, 97, 16) | 1.19 | 0.91 | 1.61 | 2.1E-01 | |
| rs1143634 | synonomous (IL1B) | G/a | 0.79 (252, 129, 19) | 0.78 (167, 106, 10) | 1.09 | 0.84 | 1.45 | 5.4E-01 | |
| rs1143633 | intron (IL1B) | T/c | 0.38 (58, 191, 150) | 0.36 (34, 135, 114) | 1.12 | 0.89 | 1.38 | 3.3E-01 | |
| RA1 | intron (IL1B) | C/t | 1.00 (399, 0, 0) | 1.00 (281, 1, 0) | NA | NA | NA | 2.3E-01 | |
| rs1143627 | 5′ non-gene region | A/g | 0.67 (181, 168, 44) | 0.66 (120, 129, 31) | 1.07 | 0.85 | 1.37 | 5.6E-01 | |
| rs16944 | 5′ non-gene region | G/a | 0.67 (177, 177, 44) | 0.66 (118, 134, 30) | 1.05 | 0.84 | 1.34 | 6.7E-01 | |
| RA3 | 5′ non-gene region | A/g | 0.80 (254, 125, 17) | 0.82 (189, 84, 8) | 0.86 | 0.65 | 1.17 | 2.9E-01 | |
| rs13013349 | 5′ non-gene region | G/a | 0.67 (180, 176, 44) | 0.66 (119, 136, 28) | 1.04 | 0.83 | 1.33 | 7.2E-01 | |
| rs13032029 | 5′ non-gene region | T/c | 0.48 (93, 196, 107) | 0.46 (56, 142, 80) | 1.11 | 0.89 | 1.37 | 3.6E-01 | |
| RA4 | 5′ non-gene region | C/g | 0.94 (357, 36, 5) | 0.91 (232, 49, 0) | 1.56 | 1.03 | 2.58 | 3.6E-02 | |
| rs4447608 | 5′ non-gene region | T/c | 0.49 (94, 198, 106) | 0.46 (55, 149, 76) | 1.09 | 0.88 | 1.36 | 4.2E-01 | |
| rs6735739 | 5′ non-gene region | C/t | 0.67 (182, 172, 44) | 0.66 (118, 138, 26) | 1.05 | 0.83 | 1.34 | 6.9E-01 | |
| rs6745746 | 5′ non-gene region | A/g | 0.47 (82, 208, 105) | 0.45 (46, 160, 76) | 1.10 | 0.89 | 1.37 | 3.8E-01 | |
| rs12053091 | 5′ non-gene region | C/t | 0.25 (23, 148, 215) | 0.23 (17, 89, 161) | 1.12 | 0.87 | 1.41 | 3.9E-01 | |