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. Author manuscript; available in PMC: 2008 Sep 10.

Published in final edited form as: J Am Chem Soc. 2006 Dec 6;128(48):15364–15365. doi: 10.1021/ja066241+

Table 1.

Kinetic Parameters of ATCh and Cocaine Hydrolysis.

Acetylthiocholine					Cocaine^a
catalyst	k_cat (min⁻¹)	K_m (μM)	k_cat/K_m (M⁻¹ s⁻¹	k_cat/k_uncat	k_cat (min⁻¹)	K_m (μM)	k_cat/K_m (M⁻¹ s⁻¹)	k_cat/k_uncat
GNL3A6	0.016 ± 0.002	910 ± 220	0.29 ± 0.08	3.0×l0² ± 0.3×l0²	0.03	55	9.2	3.7×l0³
GNL7A1	0.010 ± 0.001	1250 ± 320	0.13 ± 0.04	1.9×l0² ± 0.2×l0²	0.025 ± 0.001	750 ± 37	0.56 ± 0.04	2.7×l0³ ± 0.l×l0³
GNL4D3	0.014 ± 0.001	960 ± 110	0.23 ± 0.03	2.5×l0² ± 0.2×l0²	0.01	70	2.3	1.2×l0³
cocE	1207 ± 24	8430 ±270	2.4×l0³ ± 0.1×l0³	2.2×l0⁷ ± 0.1×10⁷	468 ± 6	0.64 ± 0.02	1.2×l0⁷ ± 0.1×10⁷	5.0×10⁷ ± 0.1×10⁷

^a

Values from references 6 and 9.

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